Charlton suffered their second defeat in a row after a Cheyenne Dunkley double saw Wigan emerge victorious.
The defender broke the deadlock after 22 minutes when he volleyed home from a Charlie Mulgrew corner.
He would grab his second of the game, and third of the season, when the defender rose highest to guide in Michael Jacobs' corner with 20 minutes remaining.
Charlton, who lost 1-0 at home to Birmingham City, now sit in eighth in the table after their impressive start saw them rise to as high as second.
Here are five things we learned...
Darren Pratley was lucky not to get sent off
Following the confusion with the drop ball situation, where Michael Jacobs ran and shot from the restart of play, Pratley got into an altercation with Wigan's Joe Williams.
The midfielder, who captained the Addicks on the day, put a hand on Williams' neck but escaped further punishment when both were spoken with by referee Andy Davies.
Charlton were already struggling to find their rhythm in the game so a red card at that juncture could have been catastrophic.
READ: Bowyer weighs in with his thoughts on VAR technology
Should Charlton have had a penalty?
On the flip side, goalscorer Dunkley pulled back Sarr inside the box in what Lee Bowyer described as a "blatant" penalty.
Replays appeared to show Mr Davies was in good view of the incident but decided against giving it.
It looked like a penalty at the time, and on replays, so why it was not given is something only the officials will know.
Valuable lessons could be learned from the Wigan defeat ahead of a tough run
Promotion chasers Leeds United, Swansea City and Fulham lie in wait of Charlton next in what will be a certainly be a difficult run of fixtures.
Bowyer said there were no positives in their defeat at Wigan but there must be some lessons to take from it into their next game.
It's up to Charlton now to see what they can take from the last two weekends and eradicate the issues which have seen them lose two in a row.
READ: Charlton striker told to strengthen key area to keep improving
Leko and Hemed might need to get on the same page sooner rather than later
The two strikers have different, but complementing, roles to play in Charlton's attack but it has not quite clicked yet.
Against Wigan, the pair rarely combined with one another to break down the defence - and when they did the chances were not very clear-cut.
Partnerships like this take time, sure, but whether Charlton have that time in the absence of their star striker, when they clearly need another supply of goals, is another question.
But Lockyer has stepped up really well since joining
The Wales international appears to have acclimatised to Championship football faster than some may have expected.
Lockyer, who has won six caps with the senior squad, plied most of his trade in League One and League Two before being given a chance in a higher tier.
It's early days still but if he continues at this pace then he could be a real coup for Charlton as they cement their status in the division.
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