Police are urging anyone who was in the area in Bermondsey when a woman was stabbed to death on Christmas Eve to get in touch.
Officers are appealing for anyone who was in the Spenlow House area between around 7pm and 11pm on December 24 who may have seen or heard anything suspicious to come forward.
They say that anyone should get in touch immediately, no matter how insignificant what they saw or heard may have seemed at the time.
It comes after a 22-year-old woman was stabbed to death at a home in Spenlow House in Jamaica Road.
Police, ambulance crews and London's Air Ambulance were called to the scene just after 10pm.
A 16-year-old boy, who was known to the victim, was arrested nearby a short time later on suspicion of murder.
He remains in custody at a south London police station.
Detective Chief Inspector Brian Howie said: "Our investigation continues and a team of detectives are working at pace to establish what happened that resulted in a young woman losing her life.
"My thoughts, and those of my team, are with her family and friends at this awful time.
"One person has been arrested, however we still need to hear from anyone who was in the Spenlow House area between 19:00hrs and 23:00hrs on Christmas Eve and may have seen or heard anything suspicious.
"I would urge anyone with any information that may be relevant to our investigation, no matter how insignificant it may have seemed at the time, to come forward immediately."
Chief Superintendent Seb Adjei-Addoh, local policing commander for Southwark, said: "This is a tragic incident and my thoughts are with the woman's family and friends at this incredibly difficult time.
"We recognise this will also have an impact on the wider community and we will have additional patrols in the area over the coming days to provide reassurance."
Anyone with information about the incident is asked to call 101 quoting CAD 5855/24Dec. Information can also be shared online.
You can also contact the independent charity Crimestoppers anonymously on 0800 555 111.
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