Blackwall Tunnel currently remains closed due to a power failure which was caused by a fire at an electrical substation in Poplar.
The Brigade were called to the scene of the blaze in Castor Lane today (March 29) shortly before 12.50pm.
The London Fire Brigade (LFB) said that disruption is likely to continue into rush hour and thousands of commuters will be affected by the closure of the tunnel.
The Rotherhithe Tunnel has also closed and DLR services have been suspended following the blaze.
Station Commander Colin Digby, who is at the scene, said: "The fire is causing power outages which could affect around 38,000 customers.
"The whole of the Docklands Light Railway line is suspended.
“Blackwall Tunnel and Rotherhithe Tunnel are also closed whilst crews work to make the scene safe."
Around 100 people were evacuated from an adjacent depot and 1,500 students were evacuated from a college at the rear of the substation.
Fire crews from Shoreditch, Bethnal Green, Shadwell and Plaistow fire stations are at the scene.
The cause of the fire is not known at this time.
A spokesperson for London Fire Brigade said: "Six fire engines and around 40 firefighters have been called to a fire at an electrical substation on Castor Lane in Poplar. Part of the ground floor of a two-storey electrical substation is alight.
"A 25-metre cordon is in place as a precaution.
"Around 100 people were evacuated from an adjacent depot and 1,500 students were evacuated from a college at the rear of the substation."
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